Beta-2 adrenergic receptor genetic polymorphisms and asthma
نویسندگان
چکیده
منابع مشابه
A Pilot Study of Polymorphism of Adrenergic Beta-2 Receptor and Mild Asthma: A Clinical and Pharmacogenetic Study
Glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. This study was designed to evaluate the genetic alleles in mild asthma.Thirty-four patients with diagnosis of mild asthma (FEV1 ≥ 80%, positive methacholine test) and body mass index (BMI ≤ 30 Kg/m2) were includ...
متن کاملA Pilot Study of Polymorphism of Adrenergic Beta-2 Receptor and Mild Asthma: A Clinical and Pharmacogenetic Study
Glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. This study was designed to evaluate the genetic alleles in mild asthma.Thirty-four patients with diagnosis of mild asthma (FEV1 ≥ 80%, positive methacholine test) and body mass index (BMI ≤ 30 Kg/m2) were includ...
متن کاملBeta-2 adrenergic receptor
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with (binds) epinephrine, a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via a downstream Ltype calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. Unlike other adr...
متن کاملa pilot study of polymorphism of adrenergic beta-2 receptor and mild asthma: a clinical and pharmacogenetic study
glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. this study was designed to evaluate the genetic alleles in mild asthma.thirty-four patients with diagnosis of mild asthma (fev1 ≥ 80%, positive methacholine test) and body mass index (bmi ≤ 30 kg/m2) were includ...
متن کاملAssociation between polymorphisms and haplotypes of the beta-2 adrenergic receptor gene and asthma in a Chinese Han population.
Conflicting data have been reported on the association of variants of the beta-2 adrenergic receptor (ADRB2) gene with asthma etiology. To provide a scientific basis for the prevention and treatment of asthma, the relationship between single nucleotide polymorphisms and haplotypes of ADRB2 and asthma was examined in a Chinese Han population. Six loci (base positions -2387, -47, 46, 79, 491, and...
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ژورنال
عنوان ژورنال: Journal of Clinical Pharmacy and Therapeutics
سال: 2009
ISSN: 0269-4727,1365-2710
DOI: 10.1111/j.1365-2710.2009.01066.x